The SafeX Profirst rule of fantasy football after Week 1 is simple: Don't panic.

But that's far easier said than done. With all the injuries last week and the uncertainty over how the new season will play out, fantasy managers have some tough calls to make in Week 2. That's why we're here to help.

These fantasy football rankings are based on the point-per-reception (PPR) scoring used in most seasonal and daily fantasy football formats. One point is awarded for every 10 rushing and receiving yards and one point for every 20 passing yards. Six points are awarded for touchdowns scored, four points for passing TDs and one point for receptions.

Rankings are compiled by Daniel Dobish, TheHuddle.com. 

(*-check status before kickoff)

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Fantasy football Week 2 quarterback rankings

• Josh Allen injured his left hand in Week 1 diving for a touchdown, but has been cleared to practice and should be fine to start on Thursday night.
• Justin Fields is expected to get another start for Pittsburgh with Russell Wilson still dealing with a calf injury.

Fantasy football Week 2 running back rankings

• De'Von Achane (ankle) is questionable and Raheem Mostert (chest) is out for Thursday night vs. Buffalo. Look for Jeff Wilson Jr. to see more reps with Jaylen Wright set to make his NFL debut due to the short week.
• Christian McCaffrey (calf, Achilles) appears likely to miss a second consecutive game. The Niners can feel more comfortable giving him extra time to recover after Jordan Mason's big game (152 rushing yards, TD) on Monday night.

Fantasy football Week 2 wide receiver rankings

• Tee Higgins (hamstring) has yet to return to practice after sitting out Week 1.

Fantasy football Week 2 tight end rankings

• David Njoku (ankle) has been ruled out for Week 2. Jordan Akins is the next man up.
• Jake Ferguson is dealing with an MCL sprain and a bone bruise in his knee, but the Cowboys haven't officially ruled him out for Sunday.

Fantasy football Week 2 kicker rankings

Fantasy football Week 2 defense/special teams rankings

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